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Could I ask who’s calling? metformin hydrochloride tablets ip 500mg uses A person’s skin pigment, which can give a person red hair or fair skin, is influenced by the melanocortin-1 (MC1R) gene receptor. The MC1R mutation that underlies a person’s red hair and the cancer-causing pathway (P13K/Akt) may help explain why red-headed individuals have a higher risk of developing melanoma, the most deadly type of skin cancer, accounting for 75 percent of all skin-cancer deaths.